SLUG (SNAI2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	Western blot: 0.5-2.0 µg/ml. Detects a band of approximately 30kDa in 293 cell lysate. Immunocytochemistry/Immunofluorescence.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	13 amino acid peptide sequence near the centre of Human Slug
Specificity	This antibody detects Slug, a member of the Snail family of zinc finger transcription factors, whose expression is induced by FGF, BMP, and TGF-beta. This antibody is not cross-reactive with Snail.
Formulation	PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	snail family transcriptional repressor 2
Database Link	Entrez Gene 20583 MouseEntrez Gene 6591 Human UniProt ID O43623
Background	Slug is a 29kD transcriptional repressor, which functions by binding to E-box motifs and inhibiting gene expression by recruiting histone deacetylase-1 (HDAC-1). Slug controls the expression of a wide variety of genes including TP53, BRCA2, PUM and CDH1, and has important roles in apoptosis and epithelial-mesenchymal transition. It is also thought to function in neural crest development. Slug expression in breast, oesophageal, and colorectal carcinomas has been correlated with poor prognosis for survival.
Synonyms	SLUGH
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Adherens junction

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