p75 NGF Receptor (NGFR) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	Western blot: 1 µg/ml; detects a band of approximately 75-80kDa in A-20 cell lysate. Immunocytochemistry.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant human CD271
Specificity	This antibody recognises CD271, a transmembrane protein of 70-75kDa, otherwise known as Nerve Growth Factor Receptor (NGFR).
Formulation	Phosphate buffered saline containing 0.02% Sodium Azide (NaN3) State: Purified State: Liquid purified IgG
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	nerve growth factor receptor
Database Link	Entrez Gene 4804 Human UniProt ID P08138
Background	CD 271 is a pro-apoptotic member of the tumour necrosis factor receptor (TNFR) family and its ligands include NGF, brain derived growth neurotrophic factor (BDNF), NT3 and NT4. CD271 has been shown to interact with tropomyosin-receptor-kinase A (TrkA) forming the high-affinity NGF receptor, while CD271 can signal alone, constituting the low-affinity NGF receptor. When signalling alone, CD271 is involved in apoptosis, neurite outgrowth during development and myelination. Mutations and changes in CD271 expression have been implicated in various pathological diseases including Alzheimer
Synonyms	TNFRSF16
Reference Data

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