Cortisol Sheep Polyclonal Antibody

Specifications

Product Data
Applications	ELISA
Recommend Dilution	ELISA (1/500-1/2500 as a recommended dilution).
Reactivity	Broad
Host	Sheep
Clonality	Polyclonal
Immunogen	Cortisol-21-hemisuccinyl-KLH/BSA/Fetuin mixture.
Specificity	This anitbody recognizes the Glucocorticoid Hormone Cortisol, produced in the adrenal cortex and involved in responses to stress. The following cross reactivities have been observed: Cortisol: 100% Corticosterone: > 90%
Formulation	PBS, pH 7.2 containing 0.09% Sodium Azide State: Ig Fraction State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Background	Cortisol is the most potent glucocorticoid produced by the human adrenal. It is synthesized from cholesterol and its production is stimulated by pituitary adrenocorticotropic hormone (ACTH) which is regulated by corticotropin releasing factor (CRF). ACTH and CRF secretions are inhibited by high cortisol levels in a negative feedback loop. In plasma a majority of cortisol is bound with high affinity to corticosteroid binding globulin (CBG or transcotin). Cortisol acts through specific intracellular receptors and affects numerous physiologic systems including immune function, glucose counter regulation, vascular tone, and bone metabolism.
Synonyms	Hydrocortisone
Reference Data

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