Sphingomyelin Synthase 1 (SGMS1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Western Blot: 5-10 µg. Immunohistochemistry. Postive Control: Brain, heart, kidney, liver, muscle and stomach.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from the Human Sphingomyelin Synthase 1 protein
Specificity	This antibody detects Sphingomyelin Synthase 1, expressed in brain, heart, kidney, liver, muscle and stomach.
Formulation	Phosphate buffered saline with 0.08% Sodium Azide as preservative State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Ligand Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	sphingomyelin synthase 1
Database Link	Entrez Gene 259230 Human UniProt ID Q86VZ5
Background	A bidirectional lipid cholinephosphotransferases capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and the inverse reaction. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. May not function strictly as a SM synthase. Inhibited by bacterial PC-phospholipase C inhibitor D609. Localized to Golgi apparatus; Golgi membrane; multi-pass membrane protein. Possibly present on Brain, heart, kidney, liver, muscle and stomach.
Synonyms	Transmembrane protein 23, SMS1, Sphingomyelin synthase 1, MOB, Medulla oblongata-derived protein
Note	Predicted Molecular Weight: 49208 kDa
Reference Data
Protein Families	Transmembrane
Protein Pathways	Metabolic pathways, Sphingolipid metabolism

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