Phosphatidic acid phosphatase type 2B (PLPP3) Rabbit Polyclonal Antibody

CAT#: AP05176PU-N

Phosphatidic acid phosphatase type 2B (PLPP3) rabbit polyclonal antibody, Aff - Purified



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CNY 5,937.00


货期*
4周

规格
    • 100 ug

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Specifications

Product Data
Applications ELISA, WB
Recommend Dilution Western Blot.
Enzyme Immunoassay.
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide derived from the phosphatidic acid phosphatase 2B protein
Specificity This antibody reacts to Phosphatidic Acid Phosphatase 2B .
Formulation Phosphate buffered saline with 0.08% sodium azide
State: Aff - Purified
State: Liquid purified IgG
Concentration lot specific
Conjugation Unconjugated
Storage Condition Ship on dry ice. Store (in aliquots) at -20°C to -70°C.
Avoid repeated freezing and thawing.
Gene Name phospholipid phosphatase 3
Background Vascular endothelial growth factor and type I collagen inducible protein (VCIP), also known as phosphatidic acid phosphatase 2b (PAP2b), was originally identified in a functional assay of angiogenesis. VCIP/PAP2b exhibits an Arg - Gly - Asp (RGD) cell adhesion sequence. Immunoprecipitation and fluorescence-activated cell sorting analyses demonstrated that VCIP-RGD is exposed to the outside of the cell surface. Retroviral transduction of VCIP can induce cell aggregation and cell-cell interactions, modestly increase p120 catenin expression and promote activation of the Fak, Akt and GSK3ß protein kinases. Expression of VCIP promoted adhesion, spreading and tyrosine phosphorylation of Fak, Shc, Cas and paxillin in endothelial cells. PAP2b/VCIP is expressed in close proximity to vascular endothelial growth factor, von Willebrand factor and {alpha}vbeta3 integrin in tumor vasculatures.
Synonyms PAP2-beta, PAP2B, VCIP
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Ether lipid metabolism, Fc gamma R-mediated phagocytosis, Glycerolipid metabolism, Glycerophospholipid metabolism, Metabolic pathways, Sphingolipid metabolism
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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