Sphingosine 1 phosphate phosphatase 2 (SGPP2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blot: 1:400; Tissue lysate should be used at 10 - 50 µg/lane.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from the sphingosine 1-phosphate phosphatase 2 protein.
Specificity	This antibody reacts to Sphingosine 1-Phosphate Phosphatase 2.
Formulation	Phosphate buffered saline with 0.08% sodium azide State: Aff - Purified State: Liquid purified
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Ship on dry ice. Store (in aliquots) at -20°C only. Avoid repeated freezing and thawing.
Gene Name	sphingosine-1-phosphate phosphatase 2
Database Link	Entrez Gene 130367 Human UniProt ID Q8IWX5
Background	Sphingosine 1-phosphate (S1P) is a highly bioactive lipid that has a myriad of biological effects both intracellularly as a second messenger and extracellularly by binding to the S1P(1 - 5)/Gprotein-coupled receptors of the endothelial differentiation gene family. Intracellularly, at least two enzymes, sphingosine kinase (1 and 2) and S1P phosphatase, regulate the activity of S1P by governing the phosphorylation of S1P. SPPase2 is localized to the endoplasmic reticulum. The enzymatic activity and localization of SPPase2 are similar to SPPase1. The tissue expression of SPPase2 was different from that of SPPase1. SPPase2 is an important member of the SPPase family which play a role in attenuating intracellular S1P signaling.
Synonyms	Sphingosine-1-phosphatase 2, SPPase2
Reference Data
Protein Families	Transmembrane
Protein Pathways	Sphingolipid metabolism

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