sphingosine 1 phosphate phosphatase 1 (SGPP1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blot: 1:200; Tissue lysate should be used at 10-50 µg/lane. Positive Control: Human brain lysate.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from the sphingosine 1-phosphate phosphatase 1 protein.
Specificity	This antibody reacts to Sphingosine 1-Phosphate Phosphatase 1.
Formulation	Phosphate buffered saline with 0.08% sodium azide State: Aff - Purified State: Liquid purified Ig
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	The antibody can be shipped on dry ice. Store (in aliquots) at -20°C only. Avoid repeated freezing and thawing.
Gene Name	sphingosine-1-phosphate phosphatase 1
Database Link	Entrez Gene 81537 Human UniProt ID Q9BX95
Background	Sphingosine 1-phosphate (S1P) is a highly bioactive lipid that has a myriad of biological effects both intracellularly as a second messenger and extracellularly by binding to the S1P(1-5)/G-protein-coupled receptors of the endothelial differentiation gene family. Intracellularly, at least two enzymes, sphingosine kinase (1 and 2) and S1P phosphatase, regulate the activity of S1P by governing the phosphorylation of S1P. Regulation of hS1Pase1 with the resultant changes in cellular and secreted S1P has important implications in cell proliferation, angiogenesis and apoptosis.
Synonyms	Sphingosine-1-phosphatase 1, SPPase1
Reference Data
Protein Families	Druggable Genome, Phosphatase, Transmembrane
Protein Pathways	Sphingolipid metabolism

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