Cacna1a Rabbit Polyclonal Antibody

CAT#: AP05131PU-N

Cacna1a rabbit polyclonal antibody, Purified



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CNY 5,937.00


货期*
4周

规格
    • 100 ug

Product images

Specifications

Product Data
Applications WB
Recommend Dilution Western Blot: 5 - 10 µg/ml.
Reactivity Rat
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide derived from the rat alpha1A calcium channel conjugated to KLH.
Specificity This antibody reacts to CACNA1A.
Formulation Phosphate buffered saline with 0.08% sodium azide
State: Purified
State: Liquid purified Ig
Concentration lot specific
Conjugation Unconjugated
Storage Condition The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only.
Avoid repeated freezing and thawing.
Gene Name calcium voltage-gated channel subunit alpha1 A
Background Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1a gives rise to p and/or q-type calcium currents. P/q-type calcium channels belong to the 'high-voltage activated' (hva) group and are blocked by the funnel toxin (ftx) and by the omega-agatoxin-IVA (omega-aga-IVA). They are however insensitive to dihydropyridines (dhp), and omega- conotoxin-GVIA (omega-ctx-GVIA). voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the poreforming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity.
Synonyms Cav2.1, Brain calcium channel I, CACH4, CACN3, CACNL1A4
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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