Bax (beta isoform) Sheep Polyclonal Antibody

Specifications

Product Data
Applications	IP
Recommend Dilution	Immunoprecipitation. Will NOT detect denatured protein by Western blot.
Reactivity	Mouse
Host	Sheep
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to amino acids 172 to 199 of the Bax beta protein
Specificity	This antibody reacts to Bax-beta.
Formulation	Phosphate buffered saline with 0.08% sodium azide State: Purified State: Liquid purified Ig
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only. Avoid repeated freezing and thawing.
Gene Name	BCL2-associated X protein
Database Link	Entrez Gene 12028 Mouse UniProt ID Q07813
Background	Bax-beta is encoded by a 1.5 kb RNA species created by the retention of intron 5 in the bax mRNA transcript. The exon4/intron5 splice junction is evolutionarily conserved and is found in both the human and mouse bax coding regions. The 630 bp intron 5 contributes 60 amino acids to the Bax-beta protein before a stop codon is encountered during translation. The Bax-beta protein is 24 kDa in size and although it contains the BH1, BH2, and BH3 domains identical to Bax, it has a unique carboxyl terminus and does not have a hydrophobic transmembrane domain (Oltvai et al., 1993). Bax-beta mRNA has been found in many mouse tissues using RT-PCR. It is found co-expressed with Bax-alpha in lung, stomach, kidney, thymus, lymph node, bone marrow, pancreas, and spleen. Bax-beta mRNA was very abundant in brain and duodenum with almost no Bax-alpha mRNA detected in these tissues (Oltvai et al., 1993).
Synonyms	Apoptosis regulator BAX, BCL2L4, Bcl2-L-4
Reference Data

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