Vsx2 (C-term) Sheep Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western Blot: 0.5-1.0 mg/ml. Detects a 46 kDa band in Mouse and Rat retinal tissue lysates. Immunohistochemistry on Frozen Sections. Suitable for use againt recombinant proteins conjugated to OVA, GST, His tags and others.
Reactivity	Mouse, Rat
Host	Sheep
Clonality	Polyclonal
Immunogen	A recombinant protein corresponding to amino acids 264 to 361 derived from the C terminal of the Human Chx10 protein conjugated to KLH.
Specificity	This antibody recognizes chx 10 (C-Term). Other species not tested.
Formulation	PBS containing 0.08% Sodium Azide as preservative. State: Purified State: Liquid purified IgG fraction.
Purification	Ammonium Sulfate Precipitation
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Predicted Protein Size	46 kDa
Gene Name	visual system homeobox 2
Database Link	Entrez Gene 171360 RatEntrez Gene 12677 Mouse UniProt ID Q61412
Background	Chx10 is a 46kDa homeodomain protein of the paired-like class that is essential for development of the mammalian eye. Mutations in Chx10 cause microphthalmia, a cause of congenital blindness in humans, and the ocular retardation (or) phenotype in mice. In the developing mouse retina Chx10 is expressed in retinal progenitors, while in the mature retina, Chx10 expression becomes restricted to bipolar neurons. Concurrent with these expression patterns, the Chx10-/- (or) retina is thin due to a defect in proliferation of retinal progenitors, and lacks bipolar neurons. Chx10 is also expressed in the developing brainstem, thalamus, and spinal cord.
Synonyms	HOX10
Reference Data

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