Arhgef2 Sheep Polyclonal Antibody

Specifications

Product Data
Applications	IF, IP, WB
Recommend Dilution	Western Blot: 4 µg/ml. Detects a 118 kDa band in Mouse tissue extracts corresponding to wild-type LFC. Immunoprecipitation: 4 µg/ml. Immunofluorescence.
Reactivity	Mouse
Host	Sheep
Clonality	Polyclonal
Immunogen	Antibody developed using protein corresponding to amino acids 2 to 447 of the Lfc protein fused to GST.
Specificity	This antibody recognizes LCF.
Formulation	Phosphate Buffered Saline and 0.08% Sodium Azide State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only. Avoid repeated freezing and thawing.
Gene Name	rho/rac guanine nucleotide exchange factor (GEF) 2
Database Link	Entrez Gene 16800 Mouse UniProt ID Q60875
Background	Lfc is a 118 kDa protein discovered in a screen for oncogenes in NIH 3T3 cells. Lfc is a signaling protein related to Lbc and is part of the Dbl family of proteins. Lfc is a guanine-nucleotide exchange factor (GEF) for the Rho family of small GTPases. Lfc has also been shown to be upstream of the serine-threonine kinase JNK. Lfc has also been shown to mediate the activation of the Rac signaling pathway.
Synonyms	KIAA0651, LFP40, GEF-H1
Reference Data

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