Epstein Barr Virus / EBV EBNA 3A Sheep Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blot: 0.25-1.00 µg/ml.  Positive Control: EBV infected tissues and cells.
Reactivity	Epstein Barr Virus
Host	Sheep
Clonality	Polyclonal
Immunogen	Recombinant EBNA-3A protein.
Specificity	This antibody recognizes this antigen EBNA-3A (MW 145 kDa) on an immunoblot of EBV infected cells (EBV +ve).
Formulation	PBS State: Purified State: Liquid (0.2µm sterile filtered) purified Ig fraction Preservative: 0.08% Sodium Azide
Concentration	lot specific
Purification	Ammonium Sulfate Precipitation
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Predicted Protein Size	102.4 kDa
Background	EBNA-3A is a latent viral nuclear protein expressed in EBV transformed lymphoblastic cell lines. It is also found in some immunoblastic lymphomas in vivo. This viral nuclear protein is essential for EBV mediated transformation of B lymphocytes. The EBNA-3A functions as a transcriptional regulator though the target genes are currently unknown. Plays an essential role for activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA3A probably contributes to a negative autoregulatory control loop.
Synonyms	HHV4, HHV-4
Reference Data

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