Lat2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Suitable for Western Blotting under Non-reducing conditions: 1 μg/ml Positive control: mouse spleen. Sample preparation: Mix lysate with non-reducing SDS-PAGE sample buffer.
Reactivity	Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant N-terminal cytoplasmic domain (aa 124-203) of mouse NTAL.
Specificity	The polyclonal antibody recognizes N-terminal cytoplasmic domain of mouse Non-T cell Activation Linker (NTAL), also known as LAB (linker of activated B cells), a 25 kDa transmembrane adaptor protein present in membrane microdomains (rafts) of B cells, NK cells and myeloid cells. Negative Species: Human.
Formulation	PBS, pH 7.4 with 15 mM sodium azide as preservative. State: Aff - Purified State: Liquid purified IgG fraction (> 95% pure by SDS-PAGE).
Concentration	lot specific
Purification	Protein-A affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	linker for activation of T cells family, member 2
Database Link	Entrez Gene 56743 Mouse UniProt ID Q9JHL0
Background	NTAL (Non-T cell activation linker), also known as LAB (Linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.
Synonyms	LAB, NTAL, WBS15, WBSCR5, HSPC046
Reference Data

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