HDAC5 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Suitable for use in Western blot (1/500-1/1000) and Immunohistochemistry (1/50-1/100).
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide Sequenece around amino acids 496~500 (T-Q-S-S-P) derived from Human HDAC5.
Specificity	HDAC5 antibody AP02669PU detects endogenous levels of total HDAC5 protein.
Formulation	PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide and 50% Glycerol. State: Aff - Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Purification	Immunoaffinity Chromatography using epitope-specific immunogen.
Conjugation	Unconjugated
Storage Condition	Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	histone deacetylase 5
Database Link	Entrez Gene 10014 Human UniProt ID Q9UQL6
Background	HDAC5 is a member of the class II mammalian histone deacetylase family, which is structurally related to yeast HDA1. Human HDAC5 is composed of 1122 amino acid residues. The deacetylase domain of HDAC5 is located at the C-terminal half of the molecule. The N-terminal non-deacetylase domain does not show any significant homology with any published sequence.Both domains are required for HDAC5-mediated repression of gene transcription. HDAC5 interacts with a growing number of transcriptional factors including MEF2A as well as other HDAC proteins. The interacting complexes bind to specific regions of chromatin and regulate gene transcription in these regions.
Synonyms	Histone deacetylase 5, HD5, KIAA0600, Antigen NY-CO-9
Note	Molecular Weight: 124 kDa
Reference Data

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