Zonulin (GGVLVQPG) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC
Recommend Dilution	ELISA: 1/1000. Immunohistochemistry on Cryo Sections (Ref.1,2). Immunohistochemistry on Paraffin Sections: 1/300.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic Zonulin peptide (GGVLVQPG) KLH-conjugated.
Specificity	This antibody detects Human Zonulin. Other species not tested.
Formulation	State: Serum State: Lyophilized Serum
Reconstitution Method	Restore in aqua bidest to initial volume.
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month  or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Background	Zonulin is a protein that participates in tight junctions between cells of the wall of the digestive tract. Initially discovered in 2000 as the target of zonula occludens toxin, secreted by cholera pathogen Vibrio cholerae, it has been implicated in the pathogenesis of coeliac disease and diabetes mellitus type 1. It is being studied as a target for vaccine adjuvants. ALBA Therapeutics is developing a zonulin receptor antagonist, AT-1001, that is currently in phase 2 clinical trials.
Reference Data

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