MAPT / TAU pSer404 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blot: 1/500-1/1000.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Specificity	This antibody detects endogenous levels of Tau pSer404 protein.
Formulation	Phosphate buffered saline (PBS), pH~7.2 containing 0.05% Sodium Azide as preservative. State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Concentration	1.0 mg/ml
Purification	Affinity Chromatography using epitope-specific immunogen.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	~78.0 kDa
Gene Name	microtubule associated protein tau
Database Link	Entrez Gene 4137 Human UniProt ID P10636
Background	Tau can be phosphorylated by several protein kinases. Phosphorylation by Tau protein kinase II at Serine 404 is primarily responsible for the functional loss of Tau-mediated tubulin polymerization. In addition, phosphorylation of microtubule-associated Tau results in the dissociation of Tau from the microtubules and tubulin depolymerization. Serine 412 of Tau is modified by Tau protein kinase I/glycogen synthase kinase-3 beta (TPKI/GSK-3β) to disrupt neuronal metabolism in anatomical areas vulnerable to Alzheimer’s disease. TPKI/GSK-3β is expressed primarily in neurons and especially in neurites early in development, whereafter the distribution is concentrated mostly in the cell soma and the proximal neurite region
Synonyms	MAPTL, MTBT1, Microtubule-associated protein tau, PHF-tau, Neurofibrillary tangle protein, Paired helical filament-tau
Reference Data

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