MAPT / TAU pSer404 Rabbit Polyclonal Antibody

CAT#: AP01708PU-N

MAPT / TAU pSer404 rabbit polyclonal antibody, Aff - Purified

Size: 100 ug 25 ul



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CNY 1,999.00

CNY 4,640.00


货期*
2周

规格
    • 100 ug

Product images

Specifications

Product Data
Applications WB
Recommend Dilution Western Blot: 1/500-1/1000.
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Specificity This antibody detects endogenous levels of Tau pSer404 protein.
Formulation Phosphate buffered saline (PBS), pH~7.2 containing 0.05% Sodium Azide as preservative.
State: Aff - Purified
State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Concentration 1.0 mg/ml
Purification Affinity Chromatography using epitope-specific immunogen.
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Predicted Protein Size ~78.0 kDa
Gene Name microtubule associated protein tau
Background Tau can be phosphorylated by several protein kinases. Phosphorylation by Tau protein kinase II at Serine 404 is primarily responsible for the functional loss of Tau-mediated tubulin polymerization. In addition, phosphorylation of microtubule-associated Tau results in the dissociation of Tau from the microtubules and tubulin depolymerization. Serine 412 of Tau is modified by Tau protein kinase I/glycogen synthase kinase-3 beta (TPKI/GSK-3β) to disrupt neuronal metabolism in anatomical areas vulnerable to Alzheimer’s disease. TPKI/GSK-3β is expressed primarily in neurons and especially in neurites early in development, whereafter the distribution is concentrated mostly in the cell soma and the proximal neurite region
Synonyms MAPTL, MTBT1, Microtubule-associated protein tau, PHF-tau, Neurofibrillary tangle protein, Paired helical filament-tau
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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