Neurotensin Receptor 2 (NTSR2) Rabbit Polyclonal Antibody
CAT#: AP01326PU-N
Neurotensin Receptor 2 (NTSR2) rabbit polyclonal antibody, Aff - Purified
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CNY 4,640.00
货期*
2周
规格
Cited in 1 publication. |
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommend Dilution | Western Blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200. Immunohistochemistry on paraffin sections: 1/50-1/200. |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Specificity | NTR2 antibody detects endogenous levels of NTR2 protein. (region surrounding Asp184) |
Formulation | Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. State: Aff - Purified State: Liquid purified Ig fraction |
Concentration | 1.0 mg/ml |
Purification | Affinity chromatography |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Predicted Protein Size | ~ 45 kDa |
Gene Name | neurotensin receptor 2 |
Database Link | |
Background | Neurotensin (NT) initiates an intracellular response by interacting with the G protein-coupled receptors NTR1 (NTS1 receptor, high affinity NTR) and NTR2 (NTS2 receptor, levocabastine-sensitive neurotensin receptor), and the type I receptor NTR3 (NTS3 receptor, sortilin-1, Gp95). NT has a wide distribution in regions of the brain and in peripheral tissues where NT receptors can contribute to hypotension, hyperglycemia, hypothermia, antinociception and regulation of intestinal motility and secretion. HL-60 cells express NTR1, which can couple to Gq, Gi/o or Gs. Alternative splicing of rat NTR2 can generate a 5-transmembrane domain variant isoform that is coexpressed with the full length NTR2 throughout the brain and spinal cord. NTR3 activation in the murine microglial cell line N11 induces MIP-2, MCP-1, IL-1β and TNFα in an ERK1/2 and Akt kinase-dependent manner. |
Synonyms | NT-R-2, NTR2, NTSR2 |
Reference Data |
Citations (1)
The use of this Antibodies has been cited in the following citations: |
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Heightened Exploratory Behavior Following Chronic Excessive Ethanol Drinking: Mediation by Neurotensin Receptor Type 2 in the Anterior Paraventricular Thalamus
,Pandey, S;Barson, JR;,
Alcohol. Clin. Exp. Res.
,PubMed ID 32623746
[NTSR2]
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