Bombesin Receptor 3 (BRS3) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IF, WB
Recommend Dilution	Western blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to amino acids 280-330 of Human BRS-3.
Specificity	This antibody detects endogenous levels of BRS3 (region surrounding Cys203).
Formulation	Phosphate buffered saline (PBS), pH 7.2 State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.05% Sodium azide
Concentration	1.0 mg/ml
Purification	Affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	~ 44 kDa
Gene Name	bombesin like receptor 3
Database Link	Entrez Gene 680 Human UniProt ID P32247
Background	Bombesin receptor subtype-3 (BRS3) is an integral membrane protein belonging to the G protein-coupled receptor 1 family. The gene encoding for the BRS3 protein maps against chromosome Xq26-q28. BRS3 is important in sperm cell division, maturation and function. Its actions are mediated by G protein interactions which activate a phosphatidylinositol-calcium second messenger system. BRS3 is expressed in germ cells in testis and in lung carcinoma cells. Unlike other bombesin proteins, BRS3 does not seem to be detected in the gut and central nervous system, but has been found in rat gastrointestinal tract. Mice lacking the gene encoding for BRS3 develop obesity, suggesting that BRS3 may play a role in the regulation of plasma insulin concentration.
Synonyms	BRS-3, Bombesin receptor subtype-3
Reference Data

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