TSG6 (TNFAIP6) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	ELISA: 1/1000-1/5000. Western Blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200. Immunohistochemistry on Paraffin Sections: 1/50-1/200.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to the N-terminal of Human TSG-6.
Specificity	This antibody detects endogenous levels of TSG-6 protein. (region surrounding Val37)
Formulation	PBS, pH~7.2 with 50% glycerol State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE). Preservative: 15 mM Sodium Azide
Concentration	1.0 mg/ml
Purification	Affinity Chromatography using epitope-specific immunogen.
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	~32 kDa
Gene Name	TNF alpha induced protein 6
Database Link	Entrez Gene 7130 Human UniProt ID P98066
Background	TSG6 is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is involved in extracellular matrix stability and cell migration. This protein forms a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhances the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. The expression of this gene can be induced by tumor necrosis factor alpha and interleukin-1. The expression can also be induced by mechanical stimuli in vascular smooth muscle cells, and is correlated with proteoglycan synthesis and aggregation.
Synonyms	TSG6, TSG-6
Reference Data

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