Fibrinogen Rabbit Polyclonal Antibody
CAT#: AP00766PU-N
Fibrinogen rabbit polyclonal antibody, Purified
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CNY 14,475.00
货期*
5周
规格
Cited in 5 publications. |
Product images
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Specifications
Product Data | |
Applications | ELISA, WB |
Recommend Dilution | ELISA. Western Blot. |
Reactivity | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Native Mouse Fibrinogen. |
Specificity | This antibody recognizes Mouse Fibrinogen. Cross reacts with Fibrin. |
Formulation | 0.05M Sodium Phosphate, pH 6.6 containing 0.1M Sodium Chloride and 1 mM EDTA State: Purified State: Liquid purified Ig fraction Preservative: None |
Concentration | lot specific |
Purification | Protein A Chromatography |
Conjugation | Unconjugated |
Storage Condition | Upon receipt, store (in aliquots) at -20°C to -80°C. Avoid repeated freezing and thawing. |
Background | Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel A. et al, and Rapold H.J. et al). All these facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases. |
Synonyms | FGA, FGB, FGG |
Reference Data |
Citations (5)
The use of this Antibodies has been cited in the following citations: |
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ADAMTS13 maintains cerebrovascular integrity to ameliorate Alzheimer-like pathology
,Cao, Y;Xu, H;Zhu, Y;Shi, MJ;Wei, L;Zhang, J;Cheng, S;Shi, Y;Tong, H;Kang, L;Lu, L;Luo, H;Yang, X;Bai, X;Wang, R;Ma, Y;Wang, Y;Wang, Z;Zhong, K;Zhao, BQ;Fan, W;,
PLoS Biol.
,PubMed ID 31185010
[Fibrinogen]
|
Transfusion of Resting Platelets Reduces Brain Hemorrhage After Intracerebral Hemorrhage and tPA-Induced Hemorrhage After Cerebral Ischemia
,null,
Frontiers in Neuroscience
,PubMed ID 31024246
|
Tissue Plasminogen Activator Neurotoxicity is Neutralized by Recombinant ADAMTS 13
,Fan M, Xu H, Wang L, Luo H, Zhu X, Cai P, Wei L, Lu L, Cao Y, Ye R, Fan W, Zhao BQ,
Sci Rep
,PubMed ID 27181025
|
Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation
,Langhauser F, Gvb E, Kraft P, Geis C, Schmitt J, Brede M, Gvbel K, Helluy X, Pham M, Bendszus M, Jakob P, Stoll G, Meuth SG, Nieswandt B, McCrae KR, Kleinschnitz C,
Blood
,PubMed ID 22936662
|
C1-inhibitor protects from brain ischemia-reperfusion injury by combined antiinflammatory and antithrombotic mechanisms
,Heydenreich N, Nolte MW, GC6b E, Langhauser F, Hofmeister M, Kraft P, Albert-Weissenberger C, Brede M, Varallyay C, GC6bel K, Meuth SG, Nieswandt B, Dickneite G, Stoll G, Kleinschnitz C,
Stroke
,PubMed ID 22744646
[FG]
|
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