PDE1A Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, IP, WB
Recommend Dilution	Western blot (1/2000 as a guideline). Immunoprecipitation. Immunohistochemistry.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Designed from the C-terminal region common to all known 1A isoforms.
Specificity	The antibody selectively detects proteins corresponding to the PDE1A sub-family (See Figure 1).
Formulation	PBS containing 0.05% Sodium Azide as preservative State: Serum State: Liquid Diluted Serum
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20 to -80°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	61 kDa (Predicted)
Gene Name	phosphodiesterase 1A
Database Link	Entrez Gene 5136 Human UniProt ID P54750
Background	Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3',5'-monophosphate (cAMP and cGMP). Thus, these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling. PDE1 has three subtypes, PDE1A, PDE1B and PDE1C. PDE1A and PDE1B have higher affinity for cGMP than for cAMP, whereas PDE1C has high affinity for both cAMP and cGMP.
Synonyms	Phosphodiesterase 1A, Phosphodiesterase-1A calmodulin-dependent, Cam-PDE 1A, HSPDE1A, HCAM1, hCam-1
Reference Data

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