Mfn2 (370-600, Cytopl. Dom.) Mouse Monoclonal Antibody [Clone ID: S153-5]

Specifications

Product Data
Clone Name	S153-5
Applications	IF, IHC, WB
Recommend Dilution	Western blot: 1/1000; 1 μg/ml was sufficient for detection of Mitofusin-2 in 20 μg of mouse cardiac mitochondrial lysate by colorimetric immunoblot using HRP conjugated secondary antibody. Immunocytochemistry. Immunohistochemistry:Free floating sections, fixed in formaldehyde.
Reactivity	Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Fusion protein amino acids 370-600 (Cytoplasmic, N-terminus) of mouse Mitofusin-2 (Accession no. Q80U63); ~55% identity with Mitofusin-1.
Specificity	This antibody detects a 90 kDa protein. No cross-reactivity against Mitofusin-1.
Formulation	PBS pH 7.4, 50% Glycerol, 0,09% Sodium azide State: Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Protein G chromatography
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	mitofusin 2
Database Link	Entrez Gene 170731 Mouse UniProt ID Q80U63
Background	Mitofusin-2 (Mfn2) is a membrane protein of the mitochondria and is important in mitochondrial fusion in mammalian cells. Mfn2 activity has also been implicated in mitochondrial metabolism and the loss of Mfn2 may be the reason for certain metabolic modifications that are seen in individuals with obesity. Mfn2 has been associated with maintaining the membrane potential of the mitochondria. Mfn2 has been shown to hinder mitochondrial antiviral signaling by inhibiting production of type 1 interferons. Mfn2 is a p53-inducible target and involved in cell proliferation, apoptosis promotion and tumor suppression.
Synonyms	MFN2, CPRP1, KIAA0214
Reference Data

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