SIGLEC10 Mouse Monoclonal Antibody [Clone ID: 5G6]

Specifications

Product Data
Clone Name	5G6
Applications	FC
Recommend Dilution	Flow cytometry: Neat - 1/10, use 10ul of the suggested working dilution to label 10e6 cells.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human SIGLEC10, fused with the Fc region of human IgG
Specificity	This antibody clone 5G6 specifically recognizes human SIGLEC10. Studies have shown that clone 5G6 does not cross react with SIGLECs 3, 5, 7, 8 and 9 (Munday J. et al.)
Formulation	PBS containing 0.09% Sodium azide and 1% BSA Label: FITC State: Purified State: Liquid purified IgG Label: Fluorescein Isothiocyanate Isomer 1
Concentration	lot specific
Purification	Affinity chromatography on Protein G
Conjugation	FITC
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Gene Name	sialic acid binding Ig like lectin 10
Database Link	Entrez Gene 89790 Human UniProt ID Q96LC7
Background	Siglec10 (Sialic acid binding Ig like lectin 10), a putative adhesion molecule and member of the Ig superfamily, is expressed by monocytes, B cells, eosinophils, and at a higher level by a subpopulation of CD16+CD56- natural killer (NK) cells. Structurally, Siglec10 is most similar to the CD33 related group of Siglecs, and preferentially binds to glycoconjugates containing alpha 2,3 or alpha2,6 linked sialic acid. Studies have shown that Siglec10 acts as a substrate for VAP1 (Vascular adhesion protein1), a glycoprotein expressed on endothelium during inflammation, which is involved in primary amine oxidation and leucocyte trafficking (Kive, E. et al.). This interaction between Siglec10 and VAP1, implicates Siglec10 in endothelial lymphocyte adhesion and in the modulation of the inflammatory microenvironment.
Synonyms	Siglec-10, SLG2
Reference Data

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