GARS Mouse Monoclonal Antibody [Clone ID: AT4E10]

Specifications

Product Data
Clone Name	AT4E10
Applications	ELISA, WB
Recommend Dilution	The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:500
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human GARS (43-289aa) purified from E. coli.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	glycyl-tRNA synthetase
Database Link	Entrez Gene 2617 Human UniProt ID P41250
Background	GARS, also known as glycyl-tRNA synthetase, is one of the aminoacyl-tRNA synthetase that charge tRNAs with their cognate amino acids. Defects in the gene encoding GlyRS is the cause of Charcot-Marie-Tooth disease type 2D (CMT2D), which is an autosomal dominant inherited disease characterized by severe weakness, atrophy and absence of deep tendon reflexes in the upper extremities. Defects in the GlyRS gene is also the cause of distal hereditary muscular neuropathy type V (HMN5), a disease similar to CMT2D, though the distal sensory involvement is less severe in HMN5 patients.
Synonyms	GARS, Glycine-tRNA ligase, GlyRS, AP-4-A synthetase, SMAD1
Reference Data
Protein Pathways	Aminoacyl-tRNA biosynthesis

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