Estrogen Receptor 1 (ESR1) Mouse Monoclonal Antibody [Clone ID: AER304]

Specifications

Product Data
Clone Name	AER304
Applications	IF, IP, WB
Recommend Dilution	Immunoprecipitation. Immunocytochemistry. Western blot: The antibody recognizes a doublet of approximately 67 kDa in non-reducing conditions.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Estrogen receptor protein purified from calf uterus
Specificity	The antibody AER304 is directed against Estrogen Receptor alpha (ERα) and recognises amino acids residues 120-170, an epitope located in the B domain of ER-alpha.
Formulation	PBS State: Purified State: Liquid purified IgG fraction Stabilizer: 50% Glycerol, 0.2% BSA Preservative: 0.02% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	estrogen receptor 1
Database Link	Entrez Gene 2099 Human UniProt ID P03372
Background	Estrogen receptor (ER) is a hormone binding molecule, which belongs to the nuclear hormone family of intracellular receptors. Estrogen receptors exist as alpha and beta forms encoded by separate genes ESR1 and ESR2. ERα and ERβ share a high degree of sequence homology and are activated by the hormone 17β-estradiol and related compounds, including phytoestrogens and xenoestrogens. Both ERα and ERβ function as transcription factors which mediate many of the biological effects of estradiol at the level of gene regulation. Both receptors and are involved in the normal development and function of numerous tissues. Studies also suggest that ER’s may be involved in a range of pathological conditions including cancers, neurodegenerative diseases and cardiovascular disease.
Synonyms	ER alpha, Estradiol receptor, ESR1, ESR, NR3A1
Reference Data

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