p53 (TP53) Mouse Monoclonal Antibody [Clone ID: Pab122]

CAT#: AM33349PU-T

p53 (TP53) mouse monoclonal antibody, clone Pab122, Purified

Size: 20 ug 100 ug



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CNY 3,223.00


货期*
5周

规格
    • 20 ug

Product images

Specifications

Product Data
Clone Name Pab122
Applications FC, IF, IHC, IP, WB
Recommend Dilution ELISA: Use BSA free Antibody for coating.
Flow Cytometry: 0.5-1 µg/million cells.
Immunofluorescence: 0.5-1 µg/ml.
Western Blotting: 0.5-1.0 µg/ml.
Immunoprecipitation: 0.5-1 µg/500 µg protein lysate.
Immunohistochemistry on Frozen Sections: 0.5-1.0 µg/ml for 30 minutes at RT.
Positive Control: MDA-MB-231 Cells. Breast or Colon carcinoma.
Reactivity Canine, Hamster, Human, Monkey, Mouse, Rat
Host Mouse
Clonality Monoclonal
Immunogen Recombinant Human wild type p53 protein expressed in E. coli.
Specificity Recognizes a conserved determinant of the p53 protein. Its epitope maps near the C-terminus end (aa 370-378) of p53. It has been used successfully to immunoprecipitate p53 oncoprotein complexes with simian virus 40 (SV40) large T antigen. Reportedly, this antibody precipitated the most ATPase-active form of T.p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
Cellular Localization: Predominantly nuclear.
Formulation 10mM PBS
State: Purified
State: Liquid purified IgG fraction from Bioreactor Concentrate
Stabilizer: 0.05% BSA
Preservative: 0.05% Sodium Azide
Concentration lot specific
Purification Protein A/G Chromatography
Conjugation Unconjugated
Storage Condition Store undiluted at 2-8°C.
DO NOT FREEZE!
Predicted Protein Size 53 kDa
Gene Name tumor protein p53
Background p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to mdm2, SV40 T antigen and human papilloma virus E6 protein p53 senses DNA damage and possibly facilitating repair. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
Synonyms Cellular tumor antigen p53, Tumor suppressor p53, Phosphoprotein p53, NY-CO-13
Reference Data
Protein Families Druggable Genome, Stem cell - Pluripotency, Transcription Factors
Protein Pathways Amyotrophic lateral sclerosis (ALS), Apoptosis, Basal cell carcinoma, Bladder cancer, Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, Glioma, Huntington's disease, MAPK signaling pathway, Melanoma, Neurotrophin signaling pathway, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Pathways in cancer, Prostate cancer, Small cell lung cancer, Thyroid cancer, Wnt signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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