CD98 (SLC3A2) Mouse Monoclonal Antibody [Clone ID: UM7F8]

Specifications

Product Data
Clone Name	UM7F8
Applications	FC, IF, IHC, IP, WB
Recommend Dilution	Comitogenic with soluble anti-CD2 and immobilized anti-CD3 monoclonal Antibodies.  Western Blot:  0.5-1 µg/ml.  Flow Cytometry:  0.5-1 µg/106 cells. Immunofluorescence:  0.5-1 µg/ml. Immunoprecipitation: 1-2 µg/500 µg protein.   Immunohistochemistry on Frozen Sections: 0.5-1 µg/ml for 30 minutes at RT.   Positive Control:  HL-60, Jurkat, MG63, HUT-78, K562, YT, U937, Hep-G2 cells, Tonsil.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Molt 13 T cell line.
Specificity	This Monoclonal Antibody UM7F8 recognizes CD98. The CD98 molecule is a heterodimer made of a disulfide-linked glycosylated heavy chain of approximately 80-90 kDa and a non-glycosylated light chain. The heavy chain is a type II integral membrane protein containing a 50-81 amino acid NH2-terminal cytoplasmic domain, a single transmembrane sequence, and a large extracellular domain. CD98 is detected on monocytes and activated cells. Cellular Localization: Cell surface, cytoplasmic.
Formulation	10mM PBS State: Purified State: Liquid purified IgG fraction from Bioreactor Concentrate Stabilizer: 0.05% BSA Preservative: 0.05% Sodium Azide
Concentration	lot specific
Purification	Protein A/G Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Predicted Protein Size	Heterodimer (125 kDa) made of a disulfide-linked glycosylated heavy chain of approximately 80-90 kDa and a non-glycosylated light chain
Gene Name	solute carrier family 3 member 2
Database Link	Entrez Gene 6520 Human UniProt ID P08195
Background	CD98 exits as a heterodimer containing a disulphide-linked glyc osylated heavy chain and a non-glycosylated light chain. It is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exist s as the heavy chain of a heterodimer, covalently bound through disulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulatio n of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized.
Synonyms	4F2hc, MDU1
Reference Data

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