ICAM3 Mouse Monoclonal Antibody [Clone ID: MA4]

Specifications

Product Data
Clone Name	MA4
Applications	ELISA, FC, IF, IHC, IP, WB
Recommend Dilution	ELISA. Western Blot. Immunoprecipitation. Flow Cytometry. Immunocytochemistry. Immunohistochemistry on Frozen Sections. Recommended Dilutions: 1/100–1/200 for Flow Cytometry, and for Immunohistochemistry with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent, and 1/100–1/1000 for Immunoblotting applications.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Derived by fusion of mouse Ag8.653 cells with spleen cells from a BALB/c mouse immunized with an ICAM-3/HEK transfectant.
Specificity	This MA4 antibody recognizes a linear epitope in domains 1 and 2 of ICAM-3. MA4 robustly inhibits apoptotic cell interaction with phagocytes.
Formulation	PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	intercellular adhesion molecule 3
Database Link	Entrez Gene 3385 Human UniProt ID P32942
Background	Intercellular adhesion molecule 3 (ICAM3) also known as CD50 (Cluster of Differentiation 50), is a type I transmembrane glycoprotein, which normally contain 2-9 immunoglobulin-like C2-type domains, and binds to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. ICAM-3 has previously been implicated in apoptotic cell clearance, although its precise role in the clearance process is ill defined.
Synonyms	ICAM-3, ICAM-R, CDw50
Reference Data

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