Cd46 Mouse Monoclonal Antibody [Clone ID: MM.1]

Specifications

Product Data
Clone Name	MM.1
Applications	ELISA, IF, IHC, WB
Recommend Dilution	Western blot: Rat testis lysate, non-reducing conditions, band size 38 kDa (Ref.1,4). Immuno Assays (Ref.1). Immunofluorescence (Ref.2-4). Immunohistochemistry on Frozen Sections (Ref.1-3). The typical starting working dilution is 1/50.
Reactivity	Rat
Host	Mouse
Clonality	Monoclonal
Specificity	The monoclonal antibody MM.1 recognizes CD46, also known as membrane cofactor protein.
Formulation	PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% BSA
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	CD46 molecule
Database Link	Entrez Gene 29333 Rat UniProt ID Q9Z0M4
Background	An immunohistological survey of rat tissues revealed that CD46 is expressed only in the testis and epididymis of adult rats more specifically, only by spermatozoa and late spermatozoal precursors. In contrast, in humans, CD46 is expressed on every cell and tissue, with the exception of erythrocytes. CD46 serves to down-regulate the activation of complement on host tissue. It functions as a cofactor by binding to C3b and C4b. Binding is permitted by factor I, a serine protease of plasma, to degrade C3b and C4b and serves to protect the host cell against autologous attack. In human, it also serves as a receptor for measles virus. Two isoforms of CD46 predominate and arise by alternative splicing of a single CD46 gene. The isoforms differ in the length. CD46 cDNA encodes a signal sequence followed by four complement control protein domains (also called short consensus repeats (SCR)).
Synonyms	TLX, MIC10
Reference Data

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