CD11c (ITGAX) Mouse Monoclonal Antibody [Clone ID: FK24]

Specifications

Product Data
Clone Name	FK24
Applications	IF, IHC
Recommend Dilution	Immunocytochemistry. Immunofluorescence. Recommended Dilutions: 1/5, Dilute antibody preferably in PBS plus 1% BSA and 0.01% Sodium Azide. Note: This antibody can be used for the identification of CD11c-positive cells using Immunofluorescence or immunoperoxidase procedures. It can thus be used for the identification of monocytes and granylocytes using either Immunofluorescence or immunoperoxidase procedures. In addition it seems useful for identification of myelomonocytic and monocytic leukemias.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	The antibody reacts with the alpha chain the 150 kD molecule of the CD11c/CD18 Integrin complex (g150/95) which is expressed on monocytes and in a lower density on granulocytes and NK-cells of peripheral blood. It also reacts with many myelomonocytic and monocytic leukemias and (weakly) with part of the T8 positive cells (OKM1-like). The Integrins are important molecules in cellular adhesion and cellular interactions.
Formulation	State: Ascites State: Liquid diluted Ascites
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	integrin subunit alpha X
Database Link	Entrez Gene 3687 Human UniProt ID P20702
Background	Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
Synonyms	ITGAX, Integrin alpha-X, Leu M5
Reference Data

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