CD11b (ITGAM) Mouse Monoclonal Antibody [Clone ID: BEAR-1]

Specifications

Product Data
Clone Name	BEAR-1
Applications	IF, IHC, IP
Recommend Dilution	Fluorescence Microscopy or Flow Cytometry (2 µg / 5x105 cells/test). Immunoprecipitation. Immunohistochemistry on Frozen Sections. Typical Starting Dilution: 1/10.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody clone Bear-1 reacts with the CD11b alpha chain of the CD11b/CD18 (p165, 95) integrin heterodimer complex present on Human NK cells, monocytes, and granulocytes. The recognized structure is the alpha chain of a heterodimer glycoprotein of Mw 165kD (alpha chain) and 95kD (beta chain).
Formulation	PBS State: Purified State: Liquid (0.2 µm filtered) purified IgG fraction Stabilizer: 0.1% BSA Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	integrin subunit alpha M
Database Link	Entrez Gene 3684 Human UniProt ID P11215
Background	CD11b is an alpha chain integrin that is expressed as heterodimer noncovalently associated with CD18. CD11b is also designated as CR3, Mac-1, Mo-1 in integrin alphaM subunit and has a molecular weight of 165-170 kDa. The protein mediates PMN and monocytes adherence to endothelium and subsequently PMN extravasation to sites of inflammation. CD11b/CD18 interacts with both matrix and cell surface proteins including the complement component iC3b, extracellular matrix proteins and the third extracellular domain of CD54. CD11b is expressed on human NK-cells, monocytes, granulocytes, T-cells, B-cells and dendritic cells. After activation the expression is upregulated.
Synonyms	ITGAM, CR3A, CR-3 alpha chain, Integrin alpha-M, MAC1
Reference Data

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