Synaptophysin (SYP) Rabbit Monoclonal Antibody [Clone ID: MRQ-40]
CAT#: AM32244PU-N
Synaptophysin (SYP) rabbit monoclonal antibody, clone MRQ-40, Supernatant
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CNY 12,938.00
货期*
5周
规格
Cited in 2 publications. |
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Specifications
Product Data | |
Clone Name | MRQ-40 |
Applications | IHC |
Recommend Dilution | Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin Sections. Recommended Dilution: 1/100-1/500. Positive Control: Pancreas. Staining pattern: Cytoplasmic. Preparation and Pretreatment 1. Cut 3-4 μm section of formalin-fixed paraffin-embedded tissue and place on positively charged slides; dry overnight at 58°C. 2. Deparaffinize, rehydrate, and epitope retrieve; the preferred method is the use of Heat Induced Epitope Retrieval (HIER) technique in conjunction with a pressure cooker. The preferred method allows for simultaneous deparaffinization, rehydration, and epitope retrieval. Upon completion, rinse with 5 changes of distilled or deionized water. 3. If using HRP detection system, place slides in peroxide block for 10 minutes; rinse. If using AP detection system, omit this step. |
Reactivity | Human |
Host | Rabbit |
Clonality | Monoclonal |
Specificity | This Antibody reacts with neuroendocrine cells of Human adrenal medulla, carotid body, skin, pituitary, thyroid, lung, pancreas and gastrointestinal mucosa. Positive staining is seen in neurons of the brain, spinal cord, retina, and Paneth’s cells in the gastrointestinal tract and gastric parietal cells. This antibody identifies normal neuroendocrine cells and neuroendocrine neoplasms. Diffuse, finely granular cytoplasmic staining is observed, which probably correlates with the distribution of the antigen within neurosecretory vesicles. The expression of synaptophysin is independent of the presence of NSE or other neuroendocrine markers. Anti-Synaptophysin is an independent broad-range marker of neural and neuroendocrine differentiation. |
Formulation | Tris Buffer State: Liquid Supernatant Stabilizer: 1% BSA Preservative: 0.09% Sodium Azide |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Gene Name | synaptophysin |
Database Link | |
Background | Synaptophysin is a synaptic vesicle glycoprotein with 4 transmembrane domain MW 38 kDa. This protein is present in the membrane of neuronal presynaptic vesicles in brain, spinal cord, retina, vesicles of adrenal medulla, neuromuscular junctions, and endocrine cells. It is also expressed by neuroendocrine cells throughout the body, both normal and neoplastic. Synaptophysin is also marker of endocrine tumors. |
Synonyms | Neuroendocrine Marker |
Reference Data |
Citations (2)
The use of this Antibodies has been cited in the following citations: |
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Chronic cigarette smoke exposure drives spiral ganglion neuron loss in mice
,null,
Scientific Reports
,PubMed ID 29636532
[SYP]
|
An isolated orbital mass with proptosis and diplopia: an uncommon metastasis from intracranial olfactory neuroblastoma in a chinese patient
,null,
OncoTargets and therapy
,PubMed ID 27601919
[SYP]
|
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