SPTAN1 Mouse Monoclonal Antibody [Clone ID: AA6]

Specifications

Product Data
Clone Name	AA6
Applications	ELISA, IHC, WB
Recommend Dilution	Western blotting: 1/1000. Immunohistochemical on Frozen Sections. Other Immunoassays for cellular and tumor biology.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Chicken red blood cell membranes purified by hypotonic lysis and mechanical enucleation. Hybridoma produced by fusion between myeloma cells and Balb/c spleen cells.
Specificity	The antibody clone AA6 is specific to the 240 kD Alpha-Fodrin molecule of all Mammalian nonerythroid cells and Chicken Alpha-Spectrin.
Formulation	PBS State: Ig Fraction State: Liquid Ig fraction Stabilizer: 1.0% BSA Preservative: 0.09% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	spectrin, alpha, non-erythrocytic 1
Database Link	UniProt ID P07751
Background	Fodrin is a universally expressed membrane associated cytoskeletal protein consisting of alpha and beta subunits. The protein is important for maintaining normal membrane structure and supporting cell surface protein function. Alpha Fodrin is one of the important targets cleaved by caspases during apoptosis. The full length 240 kDa protein can be cleaved at several sites within its sequence by activated caspases generating N terminal 150 kDa, C terminal 120 kDa, and 35 kDa major products. Cleavage of alpha Fodrin leads to membrane malfunction and cell shrinkage.
Synonyms	Spectrin non-erythroid alpha chain, Alpha-II spectrin, Fodrin alpha chain, SPTA2
Reference Data

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