Abcg2 Rat Monoclonal Antibody [Clone ID: BXP-9]
CAT#: AM32027SU-N
Abcg2 rat monoclonal antibody, clone BXP-9, Supernatant
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CNY 6,537.00
货期*
5周
规格
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Specifications
Product Data | |
Clone Name | BXP-9 |
Applications | IF, IHC, WB |
Recommend Dilution | Western blotting: Use 1/20-1/50 dilution and HRP-anti-Rat-IgG. Flow Cytometry (optimal conditions still to be defined). Immunocytochemistry: Use 1/20-1/50 on Acetone Fixed Cytospin preparations. Immunohistochemistry on Frozen Sections: 1/20 on Acetone Fixed Frozen Sections can be followed by incubation with Biotin-labeled Rabbit anti-Rat IgG (1/100) and HRP-labeled streptavidin (1/ 500). |
Reactivity | Human, Mouse |
Host | Rat |
Clonality | Monoclonal |
Immunogen | Fusion protein containing the E. coli maltose binding protein and a fragment of the Mouse bcrp protein corresponding to amino acids 221-394. |
Specificity | This Monoclonal antibody clone BXP-9 reacts with an internal epitope of bcrp, a 70 kD transmembrane half-transporter which is involved in Multidrug resistance. |
Formulation | State: Supernatant State: Serum Free Culture Supernatant Stabilizer: 0.7% BSA Preservative: 0.09% Sodium Azide |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Gene Name | ATP-binding cassette, sub-family G (WHITE), member 2 |
Database Link | |
Background | The breast cancer resistance protein (BCRP/ABCG2) is a member of the ATP-binding cassette family of drug transporters and confers resistance to various anticancer drugs. The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. |
Synonyms | Breast cancer resistance protein 1, ABCP, MXR |
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