MRP4 (ABCC4) Rat Monoclonal Antibody [Clone ID: M4I-10]

Specifications

Product Data
Clone Name	M4I-10
Applications	IF, IHC, WB
Recommend Dilution	Western blotting: Use at 1/20-1/50 dilution and anti-Rat-HRP. Immunocytochemistry: Use at 1/20 on Acetone Fixed Cytospin preparations. Immunohistochemisty on Frozen Sections: 1/20 on Acetone Fixed Frozen sections can be followed by incubation with Biotin conjugated Rabbit anti-Rat IgG (1/100) and and HRP-labeled Streptavidin (1/ 500).
Reactivity	Human
Host	Rat
Clonality	Monoclonal
Immunogen	A fusion protein containing the E. coli maltose binding protein and a fragment of the human MRP4 protein corresponding to amino acids 372-431.
Specificity	This Monoclonal antibody clone M4I-10 recognizes MRP4/ABCC4.  The M4I-10 Mab also reacts with the Mouse orthologue of the transporter molecule (Mrp4).
Formulation	State: Supernatant State: Serum Free Culture Supernatant Stabilizer: 0.7% BSA Preservative: 0.09% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.  Avoid repeated freezing and thawing.
Gene Name	ATP binding cassette subfamily C member 4
Database Link	Entrez Gene 10257 Human UniProt ID O15439
Background	ABCC4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC proteins are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions.
Synonyms	Multidrug resistance-associated protein 4, MOAT-B
Reference Data

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