Ptprr Mouse Monoclonal Antibody [Clone ID: 6A6]

Specifications

Product Data
Clone Name	6A6
Applications	IHC, IP, WB
Recommend Dilution	Immunoprecipitation. Immunoblotting. Immunohistochemistry on Frozen Sections.
Reactivity	Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant PTP-SL-GST (NCBI accession number BN000437, expression vector pGEX-2T), expressed in E.coli.
Specificity	This antibody is directed to the common part of these proteins (PTPBR7, PTP-SL and PTPPBSγ). Specificity has been tested in Immunoprecipitation, Immunohistochemistry and Immunoblotting. Crossreacts with the striatum enriched phosphatase (STEP) when using antibody in Immunoblotting (Figure 1). Additional tests for cross reactivity have not yet been performed.
Formulation	10 mM Ammonium Bicarbonate buffer State: Purified State: Lyophilized purified Ig fraction
Reconstitution Method	Dissolve in a 100 mM Tris-HCl pH8.0 buffer containing 0.05% Sodium Azide
Concentration	lot specific
Purification	Protein A Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	protein tyrosine phosphatase, receptor type, R
Database Link	Entrez Gene 19279 Mouse UniProt ID Q62132
Background	Protein tyrosine phosphatases (PTPs) are the enzymes that are instrumental in determining the spatial and temporal balance between the tyrosine phosphorylated and non-phosphorylated targets, and thus coordinately regulate these cellular responses to extracellular cues. The Ptprr gene gives rise to 4 different neuronal phosphatases which differ in length of their N-terminal part and subcellular localization. PTPBR7 (72 kDa) is receptor-like, PTP-SL (60 kDa) is membrane associated and PTPPBSγ (42 and 37 kDa) is a cytosolic phoaphatase.
Synonyms	ECPTP, PTPRQ, R-PTP-R, PCPTP1, Ch-1PTPase, NC-PTPCOM1
Reference Data

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