Pdcd1 Hamster Monoclonal Antibody [Clone ID: J43]

Specifications

Product Data
Clone Name	J43
Applications	FC
Recommend Dilution	Flow Cytometry.
Reactivity	Mouse
Host	Hamster
Clonality	Monoclonal
Immunogen	PD-1 cDNA transfectant. Donor: mouse ascites fluid. Fusion Partner: Mouse myeloma P3U1.
Specificity	This Monoclonal Antibody reacts with Mouse PD-1 (Programmed Death-1).
Formulation	PBS containing 0.02% Sodium Azide as preservative State: Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Protein G Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	programmed cell death 1
Database Link	Entrez Gene 18566 Mouse UniProt ID Q02242
Background	CD279 is 50-55kD membrane protein which is a member of the CD28 family, and functions mainly as a negative regulator of T-cell activation. CD279 has two specific ligands; CD274 (PD-L1) and CD273 (PD-L2), and their interaction is key in the balance between stimulatory and inhibitory signals needed for effective immune responses to microbes and self-tolerance. CD279 is inducibly expressed by T-cells, B-cells, NK-T-cells and monocytes upon activation. Loss of CD279 function has been associated with a number of autoimmune diseases, including rheumatoid arthritis, type I diabetes and ankylosing spondylitis. Recent studies suggest that CD279 could be targeted therapeutically in the treatment of HIV infection to reduce T-cell exhaustion.
Synonyms	Protein PD-1, hPD-1, PDCD1
Note	TEST RESULTS (Figure 1.) Tissue Distribution by Flow Cytometry Analysis: Mouse Strain: Balb/c Antibody Concentration Used: 2.0 µg/10e6 cells. Isotypic Control (shaded): Purified Hamster IgG.
Reference Data

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