Prothrombin (F2) Mouse Monoclonal Antibody [Clone ID: CaPro-20]

Specifications

Product Data
Clone Name	CaPro-20
Applications	ELISA, WB
Recommend Dilution	ELISA. Western blot.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human Prothrombin (CaPro-20) purified from plasma.
Specificity	This antibody is specific for Human Prothrombin (CaPro-20).
Formulation	PBS containing 0.02% Sodium Azide as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml. Label: Biotin State: Liquid purified IgG fraction.
Concentration	lot specific
Conjugation	Biotin
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	coagulation factor II, thrombin
Database Link	Entrez Gene 2147 Human UniProt ID P00734
Background	Prothrombin (Factor 2 in the coagulation cascade) is proteolytically cleaved at two sites by Factor Xa to form thrombin (Factor IIa) in an important step of the coagulation cascade which ultimately results in the stemming of blood loss. Thrombin being the single most important constituent of the coagulation cascade in terms of its feedback activation roles. Prothrombin also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in Prothrombin lead to various forms of thrombosis and dysprothrombinemia. Prothrombin is a 72 kDa blood clotting glycoprotein formed by and stored in the Liver. Prothrombin is present in the blood plasma and is converted to the key blood clotting agent thrombin, when blood vessels are damaged. Factor VII, another important haemostasis protein can be converted to VIIa by Factor IXa or Thrombin.
Synonyms	Coagulation factor II
Reference Data
Protein Families	Druggable Genome, Protease, Secreted Protein
Protein Pathways	Complement and coagulation cascades, Neuroactive ligand-receptor interaction, Regulation of actin cytoskeleton

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