IL8 (CXCL8) Mouse Monoclonal Antibody [Clone ID: B-K8]

Specifications

Product Data
Clone Name	B-K8
Applications	FC, FN
Recommend Dilution	Flow Cytometry (Intra-cytoplasmic). Fuctional Assay: Blocks IL-8 induced chemotaxis of Human neutrophils.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Human IL-8
Specificity	Recognises both natural and recombinant IL-8.
Formulation	PBS, Sterile-filtered through 0.22 µm and treated to remove endotoxins. Carrier and preservative free State: Azide Free State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Ion Exchange Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	C-X-C motif chemokine ligand 8
Database Link	Entrez Gene 3576 Human UniProt ID P10145
Background	IL8 is a member of the CXC chemokine family. This family of small basic heparan-binding proteins are proinflammatory and primarily mediate the activation and migration of neutrophils into tissue from peripheral blood. This chemokine is one of the major mediators of the inflammatory response and is secreted by several cell types in response to an inflammatory stimulus. It functions as a chemoattractant, and is also a potent angiogenic factor. IL8 attracts neutrophils, basophils, and T-cells, but not monocytes. Cystic fibrosis (CF) is characterized by severe lung inflammation. The inflammatory process is believed to be caused by massive overproduction of the proinflammatory protein IL8, and the high levels of IL8 in the CF lung are therefore believed to be the central mechanism behind CF lung pathophysiology.
Synonyms	CXCL8, Protein 3-10C, Emoctakin, GCP1, MDNCF, MONAP, NAP1
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways	Bladder cancer, Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Epithelial cell signaling in Helicobacter pylori infection, NOD-like receptor signaling pathway, Pathways in cancer, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway

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