VCAM1 Mouse Monoclonal Antibody [Clone ID: B-K9]

Specifications

Product Data
Clone Name	B-K9
Applications	ELISA, FC, FN
Recommend Dilution	ELISA. Flow Cytometry. Functional Assay: Blocks the cell attachment to VCAM-1.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Activated Human umbilical vein endothelial. cells. Hybridoma: Myeloma X63/AG.8653 x Balb/c spleen cells.
Specificity	Recognizes the Vascular Cellular Adhesion Molecule-1 (VCAM-1), a 110 kDa protein. Recognizes the soluble antigen.
Formulation	Phosphate-buffered saline without Carrier and preservatives. This prodcut is sterile-filtered through 0.22 µm and treated to remove Endotoxins. State: Azide Free State: Liquid purified IgG fraction.
Concentration	lot specific
Purification	Ion Exchange Chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	vascular cell adhesion molecule 1
Database Link	Entrez Gene 7412 Human UniProt ID P19320
Background	CD106 / VCAM-1 (vascular cell adhesion molecule-1) is an Ig-like cell surface adhesion molecule binding VLA-4 integrin. VCAM-1 is a potent T cell costimulatory molecule taking part in their positive selection and survival, as well as in adhesion, transendothelial migration and activation of peripheral T cells. VCAM-1 is also involved in endothelial cell-cell contacts. Whereas VCAM-1 normally mediates leukocyte extravasion to sites of tissue inflammation, tumour cells can use overexpressed VCAM-1 to escape T cell immunity. Soluble form of VCAM-1 (sVCAM-1) is an inflammatory marker and can be used also in prognosis of subsequent cariovascular events following acute coronary syndromes.
Synonyms	V-CAM 1, INCAM-100, L1CAM, VCAM-1
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways	Cell adhesion molecules (CAMs), Leukocyte transendothelial migration

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