CD2 Mouse Monoclonal Antibody [Clone ID: B-E2]

Specifications

Product Data
Clone Name	B-E2
Applications	FC, FN, IHC
Recommend Dilution	Flow Cytometry. Immunohistochemistry: 1/50. Functional Assay: Inhibits Mixed Lymphocyte Culture.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human thymocytes. Hybridoma: Myeloma X63/AG.8653 x Balb/c spleen cells.
Specificity	Recognizes the Lymphocyte Function associated Antigen-2 (LFA-2), a 50 kDa protein.
Formulation	PBS without Carrier and preservatives. This product is Sterile-filtered through 0.22 µm and treated to remove endotoxins. State: Azide Free State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Ion Exchange Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	CD2 molecule
Database Link	Entrez Gene 914 Human UniProt ID P06729
Background	CD2 which is also known as E-rosette receptor, T11 and lymphocyte-function antigen-2 (LFA-2) is expressed on T cells, thymocytes, and subset of natural killer cells. Human CD2 functions as the receptor for sheep erythrocytes, human CD58 (LFA-3), and CD15s (Sialyl Lewis X). p56lck, p59fyn, CD3eta and CD3epsilon are tyrosine-phosphorylated after CD2 stimulation. CD2 play a role in T cell activation, T- or NK-cell-mediated cytolysis, apoptosis in activated peripheral T cells, and regulation of T cell anergy.
Synonyms	SRBC, Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptor
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Cell adhesion molecules (CAMs), Hematopoietic cell lineage

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