CD193 / CCR3 Mouse Monoclonal Antibody [Clone ID: 5E8]

Specifications

Product Data
Clone Name	5E8
Applications	FC
Recommend Dilution	Flow cytometry.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody recognizes CD193 (chemokine receptor 3), an approximately 41 kDa protein expressed above all in eosinophils and basophils.
Formulation	Phosphate buffered saline (PBS) State: Purified State: Liquid Ig fraction Preservative: 15 mM sodium azide, approx. pH 7.4
Concentration	lot specific
Purification	Protein-A affinity chromatography (> 95% pure by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	C-C motif chemokine receptor 3
Database Link	Entrez Gene 1232 Human UniProt ID P51677
Background	CD193 / CCR3 is a G-protein coupled receptor for several chemokines, namely CCL11 (eotaxin), CCL26 (eotaxin-3), CCL7 (MCP-4), or CCL5 (RANTES). It is highly expressed on eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. CD193 is the key eosinophil chemokine receptor responsible for regulation of eosinophil migration and function. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1.
Synonyms	C-C chemokine receptor type 3, C-C CKR-3, CC-CKR-3, CCR-3, CKR3, CMKBR3
Reference Data

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