CD2 Mouse Monoclonal Antibody [Clone ID: TS1/8]

Specifications

Product Data
Clone Name	TS1/8
Applications	FC, FN
Recommend Dilution	Flow cytometry. Functional application: Blocking.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Cytotoxic T lymphocytes
Specificity	This antibody recognizes CD2, a 50 kDa glycoprotein present on the human peripheral blood T lymphocytes and NK cells; also expressed by all thymocytes.
Formulation	Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized Label: PE State: Liquid Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography
Conjugation	PE
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Background	CD2 (also known as LFA-2) belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection.
Reference Data

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