LARGE (LARGE1) (35-142) Mouse Monoclonal Antibody [Clone ID: LARGE-02]

Specifications

Product Data
Clone Name	LARGE-02
Applications	FC, WB
Recommend Dilution	Flow cytometry. Western blot.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant fragment of human LARGE1 (amino acids 35-142)
Specificity	This antibody recognizes human LARGE1, a glycosyltransferase localizing mainly to the Golgi apparatus. Crossreactivity with LARGE2 was not determined.
Formulation	Phosphate buffered saline (PBS) State: Purified State: Liquid Ig fraction Preservative: 15 mM sodium azide, approx. pH 7.4
Concentration	lot specific
Purification	Protein-A affinity chromatography (> 95% pure by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	LARGE xylosyl- and glucuronyltransferase 1
Database Link	Entrez Gene 9215 Human UniProt ID O95461
Background	LARGE1 serves as a glycosyltransferase which participates in glycosylation of the muscle membrane protein alpha-dystroglycan. Mutations of LARGE1 lead to hypoglycosylation of alpha-dystroglycan and cause congenital muscular dystrophy (MDC1D) associated with severe mental retardation. Altered alpha-dystroglycan glycosylation may also play a role in cancer, as hypoglycosylation of the protein and loss of laminin binding have been demonstrated in invasive carcinoma cells.
Synonyms	LARGE, KIAA0609, LARGE1, Glycosyltransferase-like protein LARGE1, Acetylglucosaminyltransferase-like 1A
Reference Data

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