Fas Ligand (FASLG) Mouse Monoclonal Antibody [Clone ID: NOK-1]

Specifications

Product Data
Clone Name	NOK-1
Applications	FC, FN, IF, IP, WB
Recommend Dilution	Flow cytometry. Immunoprecipitation. Western blot. Immunocytochemistry. Functional application: blocking.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	L5178Y mouse T lymphoma cells expressing recombinant human CD178
Specificity	This antibody recognizes CD178 / Fas-L, an approximately 40 kDa transmembrane glycoprotein expressed on neutrophils, monocytes, and activated T and NK cells.
Formulation	Phosphate buffered saline (PBS) State: Purified State: Liquid Ig fraction Preservative: 15 mM sodium azide, approx. pH 7.4
Concentration	lot specific
Purification	Protein-A affinity chromatography (> 95% pure by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	Fas ligand
Database Link	Entrez Gene 356 Human UniProt ID P48023
Background	CD178 / Fas-L (Fas ligand, CD95L), a member of TNF family transmembrane glycoproteins, is responsible for induction of apoptosis in cells containing its receptor CD95 / Fas. The CD178-mediated apoptosis pathway has been implicated in peripheral tolerance, tissue pathology, and maintenance of the immune privileged sites. Defects in this interaction may be related to some cases of systemic lupus erythematosus (SLE). CD178 was also described as a co-stimulatory receptor for T-cell activation in mice in vivo.
Synonyms	FASLG, APT1LG1, FASL, TNFSF6, CD95L protein, APTL
Reference Data

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