EPOR Mouse Monoclonal Antibody [Clone ID: VP-2E8]

Specifications

Product Data
Clone Name	VP-2E8
Applications	ELISA, FC, IP, WB
Recommend Dilution	Flow cytometry: 1.2 µg/106 cells. ELISA: 1/200 - 1/400. Cell-based ELISA: 1/200 - 1/400. Immunoprecipitation: See ref 5.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	cDNA encoding the ECD of human Epo-R. Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells.
Specificity	Recognizes Human Epo-R. Other species not tested.
Formulation	Phosphate buffered saline, pH 7.2 State: Purified State: Liquid Ig fraction
Purification	Protein G
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	erythropoietin receptor
Database Link	Entrez Gene 2057 Human UniProt ID P19235
Background	Erythropoietin receptor (Epo-R) belongs to the cytokine receptor family and is a 507 amino acid type I transmembrane protein. EpoR pre-exists as dimers which changes the homodimerized state after binding of its 34 kDa ligand erythropoietin (Epo) (1,2). Erythropoietin is the primary regulator of erythropoiesis, and promotes the survival, proliferation, and differentiation of erythroid progenitor cells. Both, Epo and Epo-R are essential for the production of red blood cells due to Epo exerts its function through the Epo receptor (3). The Epo-R is also expressed in many organs outside the bone marrow, suggesting that Epo is a pleiotropic anti-apoptotic factor. Signaling pathways have been shown to influence numerous cellular functions in normal and tumor cells, including proliferation, apoptosis, and drug resistance (4). Development and specificity testing of the antibody are described in detail elsewhere (5).
Synonyms	EPOR, EPO-R
Reference Data

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