CMKLR1 Mouse Monoclonal Antibody [Clone ID: 1A7]

Specifications

Product Data
Clone Name	1A7
Applications	IHC
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 1 µg/ml (1/200). Predigestion with proteinase K required.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	DNA vaccine
Specificity	This antbody detects Chemerin receptor. The specificity of the antibody was verified by flow cytometry with cells expressing the recombinant protein.
Formulation	Phosphate buffered saline pH 7.2 (PBS) State: Purified State: Lyophilized affinity purified Ig fraction Stabilizer: 5 mg/ml BSA Preservative: 0.1% Kathon
Reconstitution Method	Restore by adding 0.5 ml distilled water
Concentration	0.2 mg/ml (after reconstitution)
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	chemerin chemokine-like receptor 1
Database Link	Entrez Gene 1240 Human UniProt ID Q99788
Background	G-protein coupled receptor ChemR23 is a 373 amino acid protein that belongs to the G - protein coupled receptor 1 family, with two potential glycosylation sites and one disulfide bond. The ligand Chemerin (or retinoic acid receptor responder protein 2 , RARRES2) is a 14 kDa protein found to stimulate chemotaxis of dendritic cells , monocytes / macrophages and natural killer cells to the site of inflammation. Accordingly, there is abundant expression of the receptor on these cells. ChemR23 is prominently expressed in developing osseous and cartilaginous tissue, as well as in tissues associated with hematopoietic and immune function including spleen, thymus, appendix, lymph node, bone marrow and fetal liver. The rece ptor is also found in adult parathyroid glands, in the cardiovascular system, brain, kidney, gastrointestinal and myeloid tissues and on endothelial cells. ChemR23 a cts as a cor eceptor for several SIV strains, as well as a primary HIV - 1 strain.
Synonyms	CMKLR1, CHEMR23, DEZ
Reference Data

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