DEP1 (PTPRJ) (1-444) Mouse Monoclonal Antibody [Clone ID: MEM-CD148/05]

CAT#: AM26703PU-N

DEP1 (PTPRJ) (1-444) mouse monoclonal antibody, clone MEM-CD148/05, Aff - Purified

Conjugation: Unconjugated Biotin PE



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CNY 3,140.00


货期*
5周

规格
    • 100 ug

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Specifications

Product Data
Clone Name MEM-CD148/05
Applications FC
Recommend Dilution Flow Cytometry.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Human recombinant CD148 (amino acids 1-444)
Specificity The antibody recognizes CD148, a highly glycosylated up to 250 kDa receptor-like protein tyrosin phosphatase expressed mainly in lymphocytes, myeloid cells and epithelial cells.
Formulation PBS, approx. pH 7.4
State: Aff - Purified
State: Liquid purified fraction  (> 95% pure by SDS-PAGE)
Preservative: 15 mM Sodium Azide
Concentration lot specific
Purification Affinity Chromatography on Protein A
Conjugation Unconjugated
Storage Condition

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Gene Name protein tyrosine phosphatase, receptor type J
Background CD148 (also known as HPTP-eta or DEP-1) is a transmembrane protein tyrosin phosphatase containing eight fibronectin type III extracellular domains. This protein is known to inhibit transduction of mitogenic signals in non-hematopoietic cells (fibroblasts, epithelial cells), and signal transduction downstream of T cell receptor, however, it also augments immunoreceptor signaling in B cells and macrophages via dephosphorylating C-terminal tyrosine of Src-family tyrosine kinases. CD148 expression increases after in vitro activation of peripheral blood leucocytes. It can be also used as marker of the most mature human thymocytes, and leukemic cells corresponding to this stadium of thymocyte differentiation. In contrast, in mice the CD148 expression sharply drops through the double positive stage to the single positive thymocytes.
Synonyms DEP1, DEP-1, HPTP eta, R-PTP-eta, Protein-tyrosine phosphatase eta, R-PTP-J
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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