IL6 Mouse Monoclonal Antibody [Clone ID: 2E10]

Specifications

Product Data
Clone Name	2E10
Applications	ELISA, WB
Recommend Dilution	ELISA. Western blot.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant human IL-6
Specificity	The antibody is reactive with recombinant human IL-6. Reactivity with natural antigen has not been evaluated.
Formulation	0.01M PBS, pH 7.0 State: Purified State: Lyophilized Ig fraction
Reconstitution Method	Double distillated water is recommended to reconstitute the antibody.
Purification	Protein G affinity purified
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	interleukin 6
Database Link	Entrez Gene 3569 Human UniProt ID P05231
Background	Interleukin 6 (IL6) is a multifunctional 24 kDa protein originally discovered in the medium of RNA stimulated fibroblastoid cells. It is upregulated by IL1, TNF, PDGF, IFN beta, TNF alpha, NGF, IL17 and downregulated by glucocorticoids IL4, TGF beta. IL6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be as important as IL1 and TNF alpha in regulating the acute phase response. IL6 has also been implicated in regulating adipose mass. IL6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages and endothelial cells. It acts upon a variety of cells including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. In addition, IL6 appears to interact with IL2 in the proliferation of T lymphocytes. IL6 potentiates the proliferative effect of IL3 on multipotential hematopoietic progenitors.
Synonyms	IL-6, Interferon beta-2, IFNB2, B-cell stimulatory factor 2, BSF-2, CDF
Reference Data

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